郭天南博士 - 生命科学学院 - 导师团队

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导师团队

我们欢迎拥有各种学术背景的杰出学者、研究员和年轻科学家。到 2026 年，西湖大学预计将拥有 300 名助理教授、副教授和正教授（包括讲座教授），600 名研究、教学、技术支持和行政人员以及 900 名博士后研究员。

郭天南博士

Tiannan Guo, Ph. D.

生命科学学院

蛋白质组大数据实验室

联系

邮箱: guotiannan@westlake.edu.cn

网站: http://www.guomics.com

个人简介

郭天南，2006年毕业于华中科技大学同济医学院临床医学七年制，同时获得武汉大学生物科学双学位。2007-2008年曾在新加坡国立肿瘤中心从事医学研究工作。2012年获得新加坡南洋理工大学博士学位。2012-2017在瑞士苏黎世联邦理工大学Ruedi Aebersold教授实验室从事博士后研究。2017年初至七月在澳大利亚悉尼大学儿童医学研究所ProCan任Scientific Director，肿瘤蛋白质组Group Leader，悉尼大学医学院兼聘高级讲师。2017年8月加入浙江西湖高等研究院（西湖大学前身）任特聘研究员。

学术成果

数以千计的蛋白质存在于几乎所有生物体内，以不同的浓度混合，相互协作，执行各种生命活动。我们课题组的使命是在尽可能短的时间内，从尽可能小量的生物样本中，对尽可能多的蛋白质进行准确定量，进而解析生命活动的数学规律，最终实现基于蛋白质组的精准医疗，详见《年轻的蛋白质组学：华丽的诞生和成长的烦恼》。

课题组组长长期从事蛋白质组学相关研究，在蛋白质组技术开发和应用上做出多项原创性技术成果。在新加坡攻读博士学位其间，于2010年获得国家优秀自费留学生奖学金, 之后于2011年获得生命科学领域吴瑞奖学金。在Ruedi Aebersold教授实验室作为主要执行者建立了一套独特的高通量临床蛋白质组方法学（高压循环-卫星扫描质谱技术，PCT-SWATH），解决了将蛋白质组学实际应用于医学临床检验的一个核心技术难题，实现了对小量临床样本的高重复性高通量的质谱分析，并将其应用于大量的临床样本（包括前列腺癌、肾癌等）以寻找生物标志物。基于PCT-SWATH，申请者协助多国合作者们建立了首批工业级别的大型临床蛋白质组平台。此外，现正将该质谱技术应用于临床检验诊断的几个关键领域，包括肿瘤样本的异质性和肿瘤药敏性预测方向，做出一些原创性工作。

代表论文

1. Bo Shen #, Xiao Yi #, Yaoting Sun #, Xiaojie Bi #, Juping Du #, Chao Zhang #, Sheng Quan #, Fangfei Zhang, Rui Sun, Liujia Qian, Weigang Ge, Wei Liu, Shuang Liang, Hao Chen, Ying Zhang, Jun Li, Jiaqin Xu, Zebao He, Baofu Chen, Jing Wang, Haixi Yan, Yufen Zheng, Donglian Wang, Jiansheng Zhu, Ziqing Kong, Zhouyang Kang, Xiao Liang, Xuan Ding, Guan Ruan, Nan Xiang, Xue Cai, Huanhuan Gao, Lu Li, Sainan Li, Qi Xiao, Tian Lu, Yi Zhu, Huafen Liu, Haixiao Chen, Tiannan Guo. Proteomic and Metabolomic Characterization of COVID-19 Patient Sera. Cell. 2020.182(1): 59-72.

2. Xiu Nie#, Liujia Qian#, Rui Sun#, Bo Huang#, Xiaochuan Dong#, Qi Xiao#, Qiushi Zhang#, Tian Lu, Liang Yue, Shuo Chen, Xiang Li, Yaoting Sun, Li Lu, Luang Xu, Li Yan, Ming Yang, Zhangzhi Xue, Shuang Liang, Xuan Ding, Chunhui Yuan, Li Peng, Wei Liu, Xiao Yi, Mengge Lyu, Guixiang Xiao, Xia Xu, Weigang Ge, Jiale He, Jun Fan, Junhua Wu, Meng Luo, Xiaona Chang, Huaxiong Pan, Xue Cai, Junjie Zhou, Jing Yu, Huanhuan Gao, Mingxing Xie, Sihua Wang, Guan Ruan, Hao Chen, Hua Su, Heng Mei, Danju Luo, Dashi Zhao, Fei Xu, Yan Li, Yi Zhu, Jiahong Xia, Yu Hu, Tiannan Guo.Multi-organ Proteomic Landscape of COVID-19 Autopsies. Cell. 2021.184(3): 775-791.e14.

3. Shaohua Tang#, Rui Sun# , Weigang Ge# , Tingting Mao# , Liujia Qian# , Chongquan Huang# , Zhouyang Kang# , Qi Xiao , Meng Luo , Qiushi Zhang , Sainan Li , Hao Chen , Wei Liu , Bingjie Wang , Shufei Li , Xiaoling Lin , Xueqin Xu , Huanzheng Li , Lianpeng Wu , Jianyi Dai , Huanhuan Gao , Lu Li , Tian Lu , Xiao Liang , Xue Cai , Guan Ruan , Fei Xu , Yan Li , Yi Zhu* , Ziqing Kong, Jianping Huang , Tiannan Guo*. Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding. Cell Discovery. 2022.8(1): 70.

4. Jianfeng Bao#, Rui Sun#, Jingwen Ai#, Liujia Qian#, Fang Liu#, Hongyu Wang#, Lingling Tan, Xue Cai, Yingqiu Shi, Xiao Liang, Weigang Ge, Jing Wu, Chen Chen, Wenhong Zhang, Jinsong Huang & Tiannan Guo. Proteomic characterization of Omicron SARS-CoV-2 host response. Cell Discovery*. 2022.8(1): 46.

5.Xiaojie Bi#, Wei Liu#, Xuan Ding#, Shuang Liang#, Yufen Zheng#, Xiaoli Zhu#, Sheng Quan#, Xiao Yi, Nan Xiang, Juping Du, Haiyan Lyu, Die Yu, Chao Zhang Luang Xu, Weigang Ge, Jiale He, Guangjun Zhu, Donglian Wang, Hongguo Zhu, Shiyong Chen, Jun Li, Haihong Zhao, Yi Zhu, Huafen Liu, Jiaqin Xu, Bo Shen, Tiannan Guo.Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19. Cell Reports*. 2022.38(3): 110271

6.Jianfeng Bao#, Shourong Liu#, Xiao Liang#, Congcong Wang, Lili Cao, Zhaoyi Li, Furong Wei, Ai Fu, Yingqiu Shi, Bo Shen, Xiaoli Zhu, Yuge Zhao, Hong Liu, Liangbin Miao, Yi Wang, Shuang Liang, Linyan Wu, Jinsong Huang, Tiannan Guo, Fang Liu. A prediction model for COVID-19 liver dysfunction in patients with normal hepatic biochemical parameters. Life Science Alliance*. 2022.19;6(1): e202201576.

7. Fangfei Zhang#, Augustin Luna, Tingting Tan, Yingdan Chen, Chris Sander, Tiannan Guo. COVIDpro: Database for mining protein dysregulation in patients with COVID-19. bioRxiv*, Posted September 28, 2022. doi.org/10.1101/2022.09.27.509819

8. Jinlong Gao#, Jiale He#, Fangfei Zhang#, Qi Xiao, Xue Cai, Xiao Yi, Siqi Zheng, Ying Zhang, Donglian Wang, Guangjun Zhu, Jing Wang, Bo Shen, Markus Ralser, Tiannan Guo, Yi Zhu.Integration of protein context improves protein-based COVID-19 patient stratification. Clinical Proteomics. 2022.19(1): 31.

9. Tian Lu#, Yingrui Wang, Tiannan Guo. Multi-omics in COVID-19: Seeing the unseen but overlooked in the clinic. Cell Reports Medicine*. 2022.3(3): 100580.

10. Xiuqin Zhang, Dan Li, Rui Sun, Xinli Hu, Zhiqi Song, Xiaotian Ni, Hua Zhu, Tiannan Guo, Chuan Qin, Ruiping Xiao*. sRAGE alleviates SARS-CoV-2-induced pneumonia in hamster. Signal Transduction and Targeted Therapy. 2022.7(1): 36.

11. Ying Zhang#, Xue Cai#, Weigang Ge#, Donglian Wang#, Guangjun Zhu#, Liujia Qian#, Nan Xiang, Liang Yue, Shuang Liang, Fangfei Zhang, Jing Wang, Kai Zhou, Yufen Zheng, Minjie Lin,Tong Sun, Ruyue Lu, Chao Zhang, Luang Xu, Yaoting Sun, Xiaoxu Zhou, Jing Yu, Lyv Mengge , Zhu Bo Shen, Xu Hongguo, Yi Zhu, Jiaqin Xu, Tiannan Guo.Potential Use of Serum Proteomics for Monitoring COVID-19 Progression to Complement RT-PCR Detection. Journal of Proteome Research. 2022.21(1): 90-100.

12. Wanglong Gou#, Yuanqing Fu#, Liang Yue#, Geng-dong Chen#, Xue Cai#, Menglei Shuai#, Fengzhe Xu#, Xiao Yi, Hao Chen, Yi Zhu, Mian-li Xiao, Zengliang Jiang, Zelei Miao, Congmei Xiao, Bo Shen, Xiaomai Wu, Haihong Zhao, Wenhua Ling, Jun Wang, Yu-ming Chen, Tiannan Guo, Ju-Sheng Zheng.Gut microbiota may underlie the predisposition of healthy individuals to COVID-19. Journal of Genetics and Genomics. 2021.48(9): 792-802.

13. Kai Zhou#, Yaoting Sun#, Lu Li#, Zelin Zang#, Jing Wang#, Jun Li#, Junbo Liang#, Fangfei Zhang, Qiushi Zhang, Weigang Ge, Hao Chen, Xindong Sun, Liang Yue, Xiaomai Wu, Bo Shen, Jiaqin Xu, Hongguo Zhu, Shiyong Chen, Hai Yang, Shigao Huang, Minfei Peng, Dongqing Lv, Chao Zhang, Haihong Zhao, Luxiao Hong, Zhehan Zhou, Haixiao Chen, Xuejun Dong, Chunyu Tu, Minghui Li, Yi Zhu, Baofu Chen, Stan Z. Li, Tiannan Guo.Eleven routine clinical features predict COVID-19 severity uncovered by machine learning of longitudinal measurements. Computational and Structural Biotechnology Journal. 2021.19: 3640-3649.

14. Haixi Yan#, Xiao Liang#, Juping Du#, Zebao He#, Yu Wang, Mengge Lyu ,Liang Yue, Fangfei Zhang, Zhangzhi Xue, Luang Xu, Guan Ruan, Jun Li, Hongguo Zhu, Jiaqin Xu, Shiyong Chen, Chao Zhang, Dongqing Lv ,Zongmei Lin, Bo Shen, Yi Zhu, Biyun Qian, Haixiao Chen, Tiannan Guo. Proteomic and metabolomic investigation of serum lactate dehydrogenase elevation in COVID-19 patients. Proteomics. 2021.21(15): e2100002.

15. Yingrui Wang#, Qianru Zhu#, Rui Sun#, Xiao Yi#, Lingling Huang, Yifan Hu, Weigang Ge, Huanhuan Gao, Xinfu Ye, Yu Song, Li Shao, Yantao Li, Jie Li, Tiannan Guo, Junping Shi. Longitudinal proteomic investigation of COVID-19 vaccination. Protein&Cell*. (Accepted)

16. Xiao Liang, Rui Sun, Jing Wang, Kai Zhou, Jun Li, Shiyong Chen, Mengge Lyu, Sainan Li, Zhangzhi Xue, Yingqiu Shi, Yuting Xie, Qiushi Zhang, Xiao Yi, Juan Pan, Donglian Wang, Jiaqin Xu, Hongguo Zhu, Guangjun Zhu, Jiansheng Zhu, Yi Zhu, Yufen Zheng, Bo Shen, Tiannan Guo*. Proteomics Investigation of Diverse Serological Patterns in COVID-19. Molecular & Cellular Proteomics. (Accepted)

联系方式

电子邮箱：guotiannan@westlake.edu.cn

7. Fangfei Zhang#, Augustin Luna, Tingting Tan, Yingdan Chen, Chris Sander, Tiannan Guo*. COVIDpro: Database for mining protein dysregulation in patients with COVID-19. bioRxiv, Posted September 28, 2022. doi.org/10.1101/2022.09.27.509819

9. Tian Lu#, Yingrui Wang, Tiannan Guo*. Multi-omics in COVID-19: Seeing the unseen but overlooked in the clinic. Cell Reports Medicine. 2022.3(3): 100580.

10. Xiuqin Zhang, Dan Li, Rui Sun, Xinli Hu, Zhiqi Song, Xiaotian Ni, Hua Zhu, Tiannan Guo*, Chuan Qin*, Ruiping Xiao*. sRAGE alleviates SARS-CoV-2-induced pneumonia in hamster. Signal Transduction and Targeted Therapy. 2022.7(1): 36.

15. Yingrui Wang#, Qianru Zhu#, Rui Sun#, Xiao Yi#, Lingling Huang, Yifan Hu, Weigang Ge, Huanhuan Gao, Xinfu Ye, Yu Song, Li Shao, Yantao Li, Jie Li*, Tiannan Guo*, Junping Shi*. Longitudinal proteomic investigation of COVID-19 vaccination. Protein&Cell. (Accepted)

7. Fangfei Zhang#, Augustin Luna, Tingting Tan, Yingdan Chen, Chris Sander, Tiannan Guo. COVIDpro: Database for mining protein dysregulation in patients with COVID-19. bioRxiv*, Posted September 28, 2022. doi.org/10.1101/2022.09.27.509819

9. Tian Lu#, Yingrui Wang, Tiannan Guo. Multi-omics in COVID-19: Seeing the unseen but overlooked in the clinic. Cell Reports Medicine*. 2022.3(3): 100580.

10. Xiuqin Zhang, Dan Li, Rui Sun, Xinli Hu, Zhiqi Song, Xiaotian Ni, Hua Zhu, Tiannan Guo, Chuan Qin, Ruiping Xiao*. sRAGE alleviates SARS-CoV-2-induced pneumonia in hamster. Signal Transduction and Targeted Therapy. 2022.7(1): 36.

15. Yingrui Wang#, Qianru Zhu#, Rui Sun#, Xiao Yi#, Lingling Huang, Yifan Hu, Weigang Ge, Huanhuan Gao, Xinfu Ye, Yu Song, Li Shao, Yantao Li, Jie Li, Tiannan Guo, Junping Shi. Longitudinal proteomic investigation of COVID-19 vaccination. Protein&Cell*. (Accepted)