个人简介

李小波（1985-），江苏宿迁人，长期从事植物学和微生物学研究。2007年毕业于西安交通大学，获得生物工程学士学位。2007-2012年在密歇根州立大学攻读植物学博士学位。先后在斯坦福卡内基研究所（2012-2016）和普林斯顿大学（2016-2018）进行博士后研究。获得了美国遗传学会的DeLill Nasser奖(2016)，国际植物脂类代谢论坛的 Paul Stumpf奖 (2016)，以及美国植物学家协会的Robert Rabson奖 (2016)。于2018年加入西湖大学任特聘研究员。

学术成果及研究方向

长期目标：光合生物（陆地植物、藻类及光合细菌）遍布陆地和海洋，为人类提供氧气、食物、能源、材料以及药物。李小波课题组致力于阐明光合生物能量代谢及相关调控机制，开发光合生物遗传学与合成生物学研究的革命性工具，为生命科学研究和现代生物技术产业输送高素质人才。

当前研究方向：我们将采用飞速发展的基因组编辑等技术，利用西湖大学的机器人工作站、多组学平台及植物-藻类表型分析平台，对淡水和海洋藻类的能量代谢和逆境生理展开生物化学、基因组学及合成生物学研究。课题组的三大方向是：

一、环境胁迫对叶绿体能量代谢的影响。在缺氮、低温等胁迫条件下，陆地植物和藻类积累油脂，但是同时变黄并降低光合作用。这些胁迫反应的信号通路是什么？如何在环境胁迫条件下最大化光合生物的产量？这些问题的研究成果将在农业生产和藻类生物工业中有重要应用。
二、光合作用可利用光谱的拓宽。陆地植物与绿藻对太阳光中的绿光吸收有限，因而呈现绿色。海洋藻类在绿光波段具有更高效的吸收，大多呈现褐色。我们将挖掘海洋藻类的捕光元件，将其移植到绿色植物中以拓宽其光合作用所利用的光谱。本项研究进行时所开发的海洋藻类高通量遗传学工具将同时加快人类对海洋生物的了解，让人类能够更好地开发海洋资源。

三、异养生命向光合自养生命的合成生物学改造。我们将尝试多种不同的策略，探索在实验室产生人造叶绿体与人造光合生命的可能性，并在所产生新物种中实现代谢、抗逆、细胞治疗等方面功能的定制化。

代表论文

1. Jiang Y^#, Cao T^#, Yang Y, Zhang H, Zhang J, Li X*. (2023) A chlorophyll c synthase widely co-opted by phytoplankton. Science. 382(6666):92-98.

Free download: https://www.science.org/stoken/author-tokens/ST-1455/full

2. Cao T^#, Bai Y^#, Buschbeck P, Tan Q, Cantrella MB, Chen Y, Jiang Y, Liu R, Ries N, Shi X, Sun Y, Ware MA, Yang F, Zhang H, Han J, Zhang L, Huang J, Lohr M*, Peers G*, Li X*. (2023) An unexpected hydratase synthesizes the green light-absorbing pigment fucoxanthin. Plant Cell. 35(8):3053-3072.

3. Bai Y#, Cao T#, Dautermann O#, Buschbeck P, Cantrella MB, Chen Y, Lein CD, Shi X, Ware MA, Yang F, Zhang H, Zhang L, Peers G*, Li X*, Lohr M*. (2022) Proc Natl Acad Sci USA. 119(38):e2203708119.

4. Jin Z^#, Wan L^#, Zhang Y, Li X, Cao Y, Liu H, Fan S, Cao D, Wang Z, Li X, Pan J, Dong M-Q, Wu J, Yan Z*. (2022) Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes. Cell. 185:1-13.

5. Wang Y, Yang Y, Li X*. (2022) Generation, storage, and utilizations of mutant libraries. The Chlamydomonas Sourcebook. Susan Dutcher, Ursula Goodenough, Arthur Grossman, and Francis-André Wollman, eds (Elsevier). In press.

6. Fauser F#, Vilarrasa-Blasi J#, Onishi M, Ramundo S, Patena W, Millican M, Osaki J, Philp C, Nemeth M, Salomé PA, Li X, Wakao S, Kim RG, Kaye Y, Grossman AR, Niyogi KK, Merchant S, Cutler S, Walter P, Dinneny JR*, Jonikas MC*, Jinkerson RE*. (2022) Systematic characterization of gene function in the photosynthetic alga Chlamydomonas reinhardtii. Nature Genetics. 54(5):705-714.

7. Li X, Patena W, Fauser F, Jinkerson RE, Saroussi S, Meyer MT, Ivanova N, Robertson JM, Yue R, Zhang R, Vilarrasa-Blasi J, Wittkopp TM, Ramundo S, Blum S, Goh A, Laudon M, Srikumar T, Lefebvre PA, Grossman AR, Jonikas MC*. (2019) A genome-wide algal mutant library and functional screen identifies genes required for eukaryotic photosynthesis. Nature Genetics. 51(4):627-635.

· This manuscript presents the world’s first genome-wide, indexed and mapped mutant library for any unicellular photosynthetic organism; this research also reveals 303 candidate genes involved in photosynthesis (65 previously known and 238 novel)

8. Li X#, Handee W#, Kuo MH*. (2017) The slim, the fat, and the obese: guess who lives the longest? Current Genetics. 63 (1): 43-49.

9. Li X#, Zhang R#, Patena W#, Gang SS, Blum SR, Ivanova N, Yue R, Robertson JM, Lefebvre PA, Fitz-Gibbon ST, Grossman AR, Jonikas MC*. (2016) An indexed, mapped mutant library enables reverse genetics studies of biological processes in Chlamydomonas reinhardtii. The Plant Cell. 28 (2): 367-387.

· ESI highly cited paper (defined as top 1% in citation in the field of Plant & Animal Science for the publication year)

10. Handee W#, Li X#, Hall K, Li P, Benning C, Williams B, Kuo MH*. (2016) An energy-independent pro-longevity function of triacylglycerol in yeast. PLOS Genetics. 12(2): e1005878.

· Reported by over 20 websites in China and USA

11. Li X, Jonikas MC*. (2016) High-throughput genetics strategies for identifying new components of lipid metabolism in the alga Chlamydomonas reinhardtii. Lipids in plant and algae development. Yonghua Li-Beisson and Yuki Nakamura, eds (Springer Publishing), Series Subcellular Biochemistry, 86: 223-247.

12. Yang W#*, Wittkopp T#, Li X, Warakanont J, Dubini A, Catalanotti C, Kim R, Mowack EMC, Mackinder L, Aksoy M, Page MD, D’Adamo S, Saroussi S, Heinnickel M, Johnson X, Richaud P, Alric J, Boehm M, Jonikas M, Benning C, Merchant S, Posewitz MC, Grossman AR.(2015) Critical role of Chlamydomonas reinhardtii ferredoxin-5 in maintaining membrane structure and dark metabolism. Proc Natl Acad Sci USA. 112(48): 14978-14983.

13. Li X, Umen JG, Jonikas MC*. (2014) Waking sleeping algal cells. Proc Natl Acad Sci USA. 111 (44): 15610-15611.

14. Li X, Moellering ER, Liu B, Johnny C, Fedewa M, Sears BB, Kuo MH, Benning C*. (2012) A galactoglycerolipid lipase is required for triacylglycerol accumulation and survival following nitrogen deprivation in Chlamydomonas reinhardtii. The Plant Cell. 24(11): 4670-4686.

· ESI highly cited paper

15. Li X, Benning C, Kuo MH*. (2012) Rapid triacylglycerol turnover in Chlamydomonas reinhardtii requires a lipase with broad substrate specificity. Eukaryotic Cell. 11(12): 1451-1462.

Note: # denotes equal contribution; * is used to indicate corresponding authors.

联系方式

电子邮箱：lixiaobo@westlake.edu.cn
课题组常年招收博士生与博士后。除了提供全国领先的工作待遇，课题组将根据每一位成员的背景和职业发展目标量身定制培养计划。我们期待您的加盟！