个人简介

刘晓东，2011年获得澳大利亚莫纳什大学理学荣誉学士学位。2019年获得澳大利亚莫纳什大学博士学位，师从Jose Polo教授。2019-2021年在莫纳什大学和澳洲再生医学研究所从事表观遗传学和重编程相关博士后研究，2021年在英国弗朗西斯·克里克研究所及剑桥大学Kathy Niakan实验室进行基因编辑与人类胚胎发育等方向博士后研究。曾获得Carmela and Carmelo Ridolfo Prize in Stem Cell Research，发现生物医学研究所优秀博士生毕业论文奖，国际干细胞大会科学优秀奖，国家优秀自费留学生奖学金等奖项，并入选英国1851研究奖学金展览皇家委员会和欧洲分子生物学组织 (EMBO) postdoc fellowship。

学术成果及研究方向

刘晓东实验室的研究主要以应用单细胞测序和表观遗传组学测序等技术揭示了人源体细胞到诱导干细胞(iPSC)重编程过程中的动态细胞命运调控, 利用诱导重编程捕捉了原始多能干细胞，滋养层干细胞等细胞状态 （Nature Methods, 2017; Nature, 2020），并发现了重编程过程中细胞命运的调控机制和首次构建了人源三维类囊胚结构(Nature 2021)。实验室将利用前沿交叉学科技术，如单细胞多组学，时空组学，生物信息学分析和算法开发，干细胞培养和诱导重编程，小鼠，大动物及人胚胎操作，干细胞和胚胎基因编辑，谱系追踪，实时成像/激光片层扫描显微镜, 人工智能，类器官和生物材料工程等进一步了解胚胎和器官发育，诱导重编程，干细胞命运调控和终端功能细胞分化过程中的细胞命运的调控机制，并将研究成果转化到在通用型干细胞疗法，器官培养和移植等再生医学领域的应用，造福患者。欢迎有上述技术背景和研究兴趣的同道加入团队，我们也欢迎有基因细胞疗法研发，工业转化及临床应用等相关经验的同道加入。

代表论文

1. Xiaodong Liu*, Jia Ping Tan*, Jan Schröder, Asma Aberkane, John F. Ouyang, Monika Mohenska, Sue Mei Lim, Yu B.Y. Sun, Joseph Chen, Guizhi Sun, Yichen Zhou, Daniel Poppe, Ryan Lister, Amander T. Clark, Owen J. L. Rackham, Jennifer Zenker and Jose M. Polo. Modelling human blastocysts by reprogramming fibroblasts into iBlastoids. Nature 591, 627-632 (2021).

-Selected as Cover article

-Featured or highlighted in Nature, Science, The Guardian UK, NBC in US, New Scientist, Washington Post, Financial Times (UK), San Francisco Chronicle, France 24, NPR, El Pais (Spain), Cosmos Magazine, The Telegraph UK, The Spinoff NZ, ABC News in US, WebMD (US), The Scientist (US), Daily Herald (Chicago), NBC South Carolina affiliate, Daily Mail UK, The Independent UK…etc.

2. Xiaodong Liu*, John F. Ouyang*, Fernando J. Rossello*, Jia Ping Tan, Kathryn C. Davidson, Daniela S. Valdes, Jan Schröder, Yu B.Y. Sun, Joseph Chen, Anja S. Knaupp, Guizhi Sun, Hun S. Chy, Ziyi Huang, Jahnvi Pflueger, Jaber Firas, Vincent Tano, Sam Buckberry, Jacob M. Paynter, Michael R. Larcombe, Daniel Poppe, Xin Yi Choo, Carmel M. O’Brien, William A. Pastor, Di Chen, Anna L. Leichter, Haroon Naeem, Pratibha Tripathi, Partha P. Das, Alexandra Grubman, David R. Powell, Andrew L. Laslett, Laurent David, Susan K. Nilsson, Amander T. Clark, Ryan Lister, Christian M. Nefzger, Luciano G. Martelotto, Owen J. L. Rackham and Jose M. Polo. Reprogramming roadmap reveals route to human induced trophoblast stem cells. Nature 586, 101–107 (2020).

-Featured or highlighted in Science, Science Daily, Phys, EurekAlert, Scimex, ANI News, Yahoo, Big News Network, Technology Networks.

3. Xiaodong Liu*, Christian M Nefzger*, Fernando J Rossello, Joseph Chen, Anja S Knaupp, Jaber Firas, Ethan Ford, Jahnvi Pflueger, Jacob M Paynter, Hun S Chy, Carmel M O'Brien, Cheng Huang, Ketan Mishra, Margeaux Hodgson-Garms, Natasha Jansz, Sarah M Williams, Marnie E Blewitt, Susan K Nilsson, Ralf B Schittenhelm, Andrew L Laslett, Ryan Lister and Jose M Polo. Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming. Nature Methods 2017; 14:1055-1062.

4. Jaber Firas*, Xiaodong Liu*, Sue Mei Lim, Jose M. Polo. Transcription factor-mediated reprogramming: epigenetics and therapeutic potential. Immunology & Cell Biology 2015 Mar;93(3):284-9.

5. Jaber Firas*, Xiaodong Liu*, Jose M. Polo. Epigenetic memory in somatic cell nuclear transfer and induced pluripotency: Evidence and implications. Differentiation 2014 Jul;88(1):29-32.

6. Jaber Firas*, Xiaodong Liu*, Christian M. Nefzger, Jose M. Polo. GM-CSF and MEF-conditioned media support feeder-free reprogramming of mouse granulocytes to iPS cells. Differentiation 2014 Jun;87(5):193-9.

7. Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F. Ouyang, Guizhi Sun, Nathan P. Croft, Fernando J. Rossello, Rebecca Simmons, Sam Buckberry, Dulce Vargas Landin, Jahnvi Pflueger, Teresa H. Vandekolk, Zehra Abay, Yichen Zhou, Xiaodong Liu, Joseph Chen, Michael Larcombe, John M. Haynes, Catriona McLean, Sarah Williams, Siew Yeen Chai, Trevor Wilson, Ryan Lister, Colin W. Pouton, Anthony W. Purcell, Owen J. L. Rackham, Enrico Petretto & Jose M. Polo. Transcriptional signature in microglia associated with Aβ plaque phagocytosis. Nature Communications 12, Article number: 3015 (2021).

8. Anja S Knaupp, Monika Mohenska, Michael R Larcombe, Ethan Ford, Sue Mei Lim, Kayla Wong, Joseph Chen, Jaber Firas, Cheng Huang, Xiaodong Liu, Trung Nguyen, Yu B Y Sun, Melissa L Holmes, Pratibha Tripathi, Jahnvi Pflueger, Fernando J Rossello, Jan Schröder, Kathryn C Davidson, Christian M Nefzger, Partha P Das, Jody J Haigh, Ryan Lister, Ralf B Schittenhelm, Jose M Polo. TINC- A Method to Dissect Regulatory Complexes at Single-Locus Resolution- Reveals an Extensive Protein Complex at the Nanog Promoter. Stem Cell Reports 2020 Dec 8;15(6):1246-1259.

9. Uma S Kamaraj, Joseph Chen, Khairunnisa Katwadi, John F Ouyang, Yu Bo Yang Sun, Yu Ming Lim, Xiaodong Liu, Lusy Handoko, Jose M Polo, Enrico Petretto and Owen J L Rackham. EpiMogrify Models H3K4me3 Data to Identify Signaling Molecules that Improve Cell Fate Control and Maintenance. Cell Systems 2020 Oct 6;S2405-4712(20)30334-3.

10. Janette Tong, Kyung Min Lee, Xiaodong Liu, Christian M Nefzger, Prasidhee Vijayakumar, Ziarih Hawi, Ken C Pang, Clare L Parish, Jose M Polo, Mark A Bellgrove. Generation of four iPSC lines from peripheral blood mononuclear cells (PBMCs) of an Attention Deficit Hyperactivity Disorder (ADHD) individual and a healthy sibling in an Australia-Caucasian family. Stem Cell Research 34, 101353.

11. William A. Pastor, Wanlu Liu, Di Chen, Jamie Ho, Rachel Kim, Timothy Hunt, Anastasia Lukianchikov, Xiaodong Liu, Jose M. Polo, Steven E. Jacobsen and Amander T. Clark. TFAP2C regulates transcription in human naive pluripotency by opening enhancers. Nature Cell Biology 20, 553–564 (2018).

12. Joseph Chen, Christian M. Nefzger, Fernando J. Rossello, Yu B.Y. Sun, Sue Mei Lim, Xiaodong Liu, Suzan de Boer Anja S. Knaupp, Jinhua Li, Kathryn C. Davidson, Jose M. Polo, Tiziano Barberi. Fine Tuning of Canonical Wnt Stimulation Enhances Differentiation of Pluripotent Stem Cells Independent of β-Catenin-Mediated T-Cell Factor Signaling. Stem Cells 36, 822–833.

13. Christian M. Nefzger, Fernando J. Rossello, Joseph Chen, Xiaodong Liu, Anja S. Knaupp, Jaber Firas, Jacob M. Paynter, Jahnvi Pflueger, Sam Buckberry, Sue Mei Lim, Brenda Williams, Sara Alaei, Keshav Faye-Chauhan, Enrico Petreto, Susan K. Nilsson, Ryan Lister, Mirana Ramialison, David R. Powel, Owen J.L. Rackham and Jose M. Polo. Cell type of origin dictates the route to pluripotency. Cell Reports 2017 Dec 5; 21(10): 2649-2660.

14. Carmel M. O'Brien, Hun S. Chy, Qi Zhou, Shiri Blumenfeld, Jack W. Lambshead, Xiaodong Liu, Joshua Kie, Bianca D. Capaldo, Tung-Liang Chung, Timothy E. Adams, Tram Phan, John D. Bentley, William J. McKinstry, Karen Oliva, Paul J. McMurrick, Yu-Chieh Wang, Fernando J. Rossello, Geoffrey J. Lindeman, Di Chen, Thierry Jarde, Amander T. Clark, Helen E. Abud, Jane E. Visvader, Christian M. Nefzger, Jose M. Polo, Jeanne F. Loring, and Andrew L. Laslett. New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells. Stem Cells. 2017 Mar; 35(3): 626–640.

https://scholar.google.com.au/citations?user=PH1gg4QAAAAJ&hl=en

联系方式

电子邮箱：liuxiaodong@westlake.edu.cn

本实验室招聘博士后、科研助理以及博士研究生，欢迎对科研感兴趣的研究者加入，请通过电子邮件联系并附上简历。