Biography
Xiao You, with a Bachelor's degree in Macromolecular Science and Engineering from Fudan University in 2014, achieved a Ph.D. in Materials Science from the University of North Carolina at Chapel Hill in 2019. Following her doctoral studies, she pursued postdoctoral research at the University of Texas at Austin from 2019 to 2022 and subsequently at SLAC National Accelerator Laboratory's Stanford Synchrotron Radiation Lightsource from 2022 to 2023. In 2023, Xiao You joined Westlake University and established the Multidimensional Nanospectroscopy laboratory. Her research interests encompass the formation of macromolecular biocondensates, nano-scale structural heterogeneity in functional materials, and the ultrafast dynamics in liquid systems.
History
2023
Westlake Fellow at Westlake University
2019
Ph.D. in Materials Science, University of North Carolina at Chapel Hill
2014
Bachelor of Science, Fudan University
2013
Fudan University Academic Scholarship
Research
Dr. You is dedicated to pioneering state-of-the-art techniques in high-resolution near-field imaging and time-resolved spectroscopy, coupled with theoretical computations, to investigate the nanoscale structures and picosecond dynamics of bioactive molecules. Her research accomplishments include:
(1) Unveiling the pivotal role of hydrogen bonds in regulating molecular crowding and phase separation systems.
(2) Proposing dynamic mechanisms at the surface-solution interface of lipid membranes.
(3) Advancing the development of biocompatible and high-resolution single-molecule super-resolution spectroscopic imaging techniques.
Representative Publications
1. You, X.; Baiz, C. R. “Importance of Hydrogen Bonding in Crowded Environments: A Physical Chemistry Perspective”. J. Phys. Chem. A, 2022, 126 (35), 5881-5889.
2. You, X., Thakur, N., Ray, A. P., Eddy, M. T., Baiz, C. R. “A comparative study of interfacial environments in lipid nanodiscs and vesicles” Biophys. Rep., 2022, 2(3), 100066.
3. You, X., Lee, E., Xu, C., Baiz, CR. “Molecular Mechanism of Cell Membrane Protection by Sugars: A Study of Interfacial H-bond Networks”, J. Phys. Chem. Lett., 2021, 12, 39, 9602–9607
4. You, X.*, Shirley, JC., Lee, E., Baiz, CR. “Short- and Long-range Crowding Effects on Water’s Hydrogen Bond Networks”. Cell Rep. Physical Science., 2021, 2(5):100419.
5. You, X., Oh, K. I., Flanagan, J. C., Baiz, C. R., “Liquid-Liquid Phase Separation Produces Fast H-Bond Dynamics in DMSO-Water Mixtures”, J. Phys. Chem. Lett., 2020, 11, 1903-1908.
6. You, X., Casper, C.B., Lentz, E., Erie, D. A., Atkin, J.M., “Fabrication of a Biocompatible Mica/Gold Surface for Tip-Enhanced Raman Spectroscopy”, ChemPhysChem, 2020, 21, 188.
7. Huang, C.W., You, X., Diemer, P.J., Petty, A.J., Anthony, J.E., Jurchescu, O.D. and Atkin, J.M., “Micro-Raman imaging of isomeric segregation in small-molecule organic semiconductors”, Commun. Chem., 2019. 2(1), pp.1- 7.
8. Sun, H., You, X., Jiang, Y. and Peng, H. "Self-healable Electrically Conducting Wire for Wearable Micro-Electronics" Angew. Chem. Int. Ed. 2014, 53(36), 9526-9531.
9. Sun, H.; You, X.; Deng, J.; Chen, X.; Yang, Z.; Chen, P.; Peng, H. “A Twisted Wire-shaped Energy Device with Dual Functions of Photoelectric Conversion and Electrochemical Storage”, Angew. Chem. Int. Ed. 2014, 126(26), 6782-6786.
10. Sun, H., You, X., Yang, Z., Deng, J. and Peng, H. “Winding Ultrathin, Transparent, and Electrically Conductive Carbon Nanotube Sheet into High-Performance Fiber-Shaped Dye-Sensitized Solar Cell". J. Mater. Chem. A, 2013, 1, 12422- 12425.
Contact Us
Email: youxiao@westlake.edu.cn
We have open positions for postdocs, graduate students, and research assistants. Our lab is dedicated to training the future generation of scientists, providing an innovative and supportive research environment.