Zhaoqian started his B.S. at UC Davis in 2014 and received double major in General Physics together with Biochemistry and Molecular Biology in 2017. In 2018, he started BPSD (Biological Physics，Structure and Design) PhD program at University of Washington, working on Viral structures at David Veesler’s lab. After receiving his PhD degree in 2022, he stayed in Veesler lab as postdoc and will join Westlake University in January 2024.

In the past decades, we have accumulated enormous amount of knowledge about the “first contact” between virus and host, that is the viral entry and fusion mechanism. However, what happens after the virus get into its host cell is something we still barely know. Especially, there are very limited molecular description and explanation of viral genome release, assembly, and egress mechanisms. Such shortage of knowledge highly limits the development of potential antiviral drug which disrupts and inhibits viral assembly and release.

Thus, the laboratory will incorporate single particle Cryo-EM, Cryo-ET and protein-protein interaction related techniques to describe the in situ structure of pandemic potent under described viral systems together with their host cell systems. The laboratory will focus on Langya henipavirus and Alongshan virus aiming at the structural description of their viral entry, replication, release, and infection mechanism. The results will be integrated with immunology and translational medication platforms to build up a viral protection “arsenal” in response to the potential spillover events. After experimental strategy and design becoming mature, the in situ structural study on virology could be generalized into pan-cellular biology. Meanwhile, the laboratory will also develop an ultra-speed Cryo-ET sample preparation system to let in situ structure study have the time axis. That is having the ability of precious determination of viral-host interaction starting point and sample preparation capability at arbitrary time point to achieve the concept of time-resolved in situ structural biology.

*These authors contribute equally

1. Zhaoqian Wang; Moushimi Amaya; Amin Addetia; Ha V. Dang; Gabriella Reggiano; Lianying Yan; Andrew C. Hickey; Frank DiMaio; Christopher C. Broder; David Veesler ; Architecture and antigenicity of the Nipah virus attachment glycoprotein, Science, 2022, 375(6587): 1373-1378

2. Zhaoqian Wang*; Ha V. Dang*; Moushimi Amaya*; Yan Xu; Randy Yin; Lianying Yan; Andrew C. Hickey; Edward J. Annand; Bethany A. Horsburgh; Peter A. Reid; Ina Smith; John-Sebastian Eden; Kai Xu; Christopher C. Broder; David Veesler ; Potent monoclonal antibody–mediated neutralization of a divergent Hendra virus variant, Proceedings of the National Academy of Sciences of the United States of America, 2022, 119(22)

3. Wang, Z.*, McCallum, M.*, Yan, L.*, Sharkey, W., Park, Y. J., Dang, H. V., Amaya, M., Person, A., Broder, C. C., & Veesler, D. J. (2023). Structure and design of Langya virus glycoprotein antigens. bioRxiv : the preprint server for biology, 2023.08.20.554025. https://doi.org/10.1101/2023.08.20.554025

4. Young-Jun Park*; Alexandra C.Walls*; Zhaoqian Wang*; Maximillian M.Sauer; Wentao Li; M.Alejandra Tortorici; Berend-Jan Bosch; Frank DiMaio; David Veesler ; Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors, Nature Structural & Molecular Biology, 2019, 26(12): 1151-1157

5. M. Alejandra Tortorici; Nadine Czudnochowski; Tyler N. Starr; Roberta Marzi; Alexandra C. Walls; Fabrizia Zatta; John E. Bowen; Stefano Jaconi; Julia Di Iulio; Zhaoqian Wang; Anna De Marco; Samantha K. Zepeda; Dora Pinto; Zhuoming Liu; Martina Beltramello; Istvan Bartha; Michael P. Housley; Florian A. Lempp; Laura E. Rosen; Exequiel Dellota; Hannah Kaiser; Martin Montiel- Ruiz; Jiayi Zhou; Amin Addetia; Barbara Guarino; Katja Culap; Nicole Sprugasci; Christian Saliba; Eneida Vetti; Isabella Giacchetto-Sasselli; Chiara Silacci Fregni; Rana Abdelnabi; Shi-Yan Caroline Foo; Colin Havenar-Daughton; Michael A. Schmid; Fabio Benigni; Elisabetta Cameroni; Johan Neyts; Amalio Telenti; Herbert W. Virgin; Sean P. J. Whelan; Gyorgy Snell; Jesse D. Bloom; Davide Corti; David Veesler; Matteo Samuele Pizzuto ; Broad sarbecovirus neutralization by a human monoclonal antibody, Nature, 2021, 597(7874): 103-108

wangzhaoqian@westlake.edu.cn