Dr. Chengchen Guo obtained B.S. degree in Chemistry from Nanjing University in 2011. After completion of the undergraduate, he earned Ph.D. degree in Chemistry from Arizona State University in Spring 2017 with a research focus on solid-state NMR spectroscopy and biopolymers. He then joined Prof. David L. Kaplan’s group at Tufts University as a postdoctoral fellow, where his research interest is to develop protein-based biofunctional medical devices for tissue engineering and regenerative medicine.

The primary research focus is to develop functional biomaterials towards clinical translation with rational design and advanced processing. Some major research topics include:

1. Protein-based bioresorbable materials for bone tissue repair and regeneration;

2. Structure and properties of natural biopolymers (e.g. silk and collagen);

3. Functional biopolymer-based nanocomposites and their biomedical applications.

1. Ziyang Sun, Ruochuan Huang, Hao Lyu, Xin Yu, Wenzhao Wang, Jinghang Li, Xingyu Lu, Chengchen Guo*, Silk Acid as an Implantable Biomaterial for Tissue Regeneration. Adv. Health. Mater. 2023, 2301439

2. Xin Yu†, Yang Hu†, Haoyuan Shi†, Ziyang Sun, Jinghang Li, Haoran Liu, Hao Lyu, Jiujie Xia, Jingda Meng, Xingyu Lu, Jingjie Yeo*, Qiyang Lu*, Chengchen Guo*, Molecular Design and Preparation of Protein-based Soft Ionic Conductors with Tunable Properties. ACS Appl. Mater. Interfaces 2022, 14, 42, 48061-48071

3. Hao Lyu, Jinghang Li, Zhechen Yuan, Haoran Liu, Ziyang Sun, Rui Jiang, Xin Yu, Yi Hu, Ying Pei, Jie Ding, Yi Shen*, Chengchen Guo*, Supertough and Highly Stretchable Silk Protein-based Films with Controlled Biodegradability. Acta Biomaterialia 2022, 153, 149–158

4. Niping Deng, Jinghang Li, Hao Lyu, Ruochuan Huang, Haoran Liu, Chengchen Guo*, Degradable Silk-based Soft Actuator with Magnetic Responsiveness. J. Mater. Chem. B 2022, 10, 7650-7660

- “Journal of Materials Chemistry B 2022 Emerging Investigators Themed Issue”

5. Haoran Liu, Ziyang Sun*, Chengchen Guo*, Chemical Modification of Silk Proteins: Current Status and Future Prospects. Adv. Fiber Mater. 2022, 4, 705-719

6. Jinghang Li, Xin Yu, Eduardo Enciso Martinez, Jiaqing Zhu, Ting Wang, Shengwei Shi, Su Ryon Shin, Shabir Hassan*, Chengchen Guo*, Emerging Biopolymer-based Bioadhesives. Macromol. Biosci. 2021, 2100340

- Selected papers in “Best of Macromolecular Journals 2023 Edition”

7. Chengchen Guo†, Chunmei Li†, Hiep V. Vu, Philip Hanna, Aron Lechtig, Yimin Qiu, Xuan Mu, Shengjie Ling, Ara Nazarian, Samuel Lin, David L. Kaplan, Thermoplastic Moulding of Regenerated Silk. Nat. Mater. 2020, 19, 102-108. († equal contribution)

8. Chunmei Li†, Chengchen Guo†, Vincent Fitzpatrick, Ahmed Ibrahim, Myrthe Zwierstra, Philip Hanna, Aron Lechtig, Ara Nazarian, Samuel Lin, and David Kaplan, Design of biodegradable implantable devices towards clinical translation. Nat. Rev. Mater. 2020, 5, 61-81. († equal contribution)

9. Ying Chen†, Chengchen Guo†, Eleana Manousiouthakis, Xiuli Wang, Dana M. Cairns, Terrence Roh, Chuang Du, David L. Kaplan, Bi-layered Tubular Microfiber Scaffolds as Functional Templates for Engineering Human Intestinal Smooth Muscle Tissue. Adv. Funct. Mater. 2020, 2000543. († equal contribution)

10. Chengchen Guo, Chunmei Li, Xuan Mu, David L. Kaplan, Engineering Silk Materials: From Natural Spinning to Artificial Processing. Appl. Phys. Rev. 2020, 7, 011313

Email: guochengchen@westlake.edu.cn

We have several open positions for postdocs, graduate students and research assistants. Our lab is committed to training the next generation of scientists. We endeavor to provide an innovative, rigorous, and collegial research environment for our trainees, and offer continuous support for the career growth of young scientists.

Please visit https://cguosci.com/ for more information.