Biography
Dr. Linglan Fang was born and raised in Jinhua, Zhejiang province, China. He obtained his B.S. in Chemistry from China Agricultural University in 2013. In 2020, Linglan received his Ph.D. degree in Chemistry from the University of Washington in Prof. Dustin J. Maly’s laboratory. He then moved to Stanford University as a postdoctoral scholar in the laboratory of Prof. Eric T. Kool. In August 2024, Dr. Linglan Fang will join Westlake University as an assistant professor, with research interests focused on rewiring mammalian biology and chemical biotechnology development using RNA-targeted small molecules.
Research
The Fang laboratory aims to dissect small-molecule modulation of RNA functions in human physiology and diseases by developing and applying cutting-edge chemical and genomic analysis tools. In parallel, we aim to leverage our insights into small molecule-RNA interaction principles to engineer next-generation RNA modulators that harness the native cellular machinery to precisely control RNA functions.
It’s an exciting era to explore the human transcriptome with small molecules, given the emerging roles of RNA in human physiology and diseases. Despite strong progress in this field, many fundamental questions remain: Which structured RNA loci are ligandable? What is the chemical space of RNA-binding ligands? How do small molecules modulate RNA structure, interactions, and functions? Technical challenges largely limit our ability to answer these questions, and our lab aims to develop new methodologies to bridge these gaps, including:
(1) Developing high-throughput technologies to identify functional small molecule-RNA interactions that modulate cellular homeostasis and signaling.
(2) Advancing chemical and genomic analysis tools to detect small molecule-RNA interactions on a global scale.
(3) Reprogramming RNA functions with next-generation RNA modulators, particularly for RNAs linked to cancer, autoimmunity, and neurological disorders.
Representative Publications
1. Fang L, Velema WA, Lee Y, Xiao L, Mohsen MG, Kietrys AM, Kool ET, Pervasive Transcriptome Interactions of Protein-Targeted Drugs, Nat. Chem., 2023, 15, 1374-1383.
2. Fang L, Xiao L, Jun YW, Onishi Y, Kool ET, Reversible 2´-OH Acylation Enhances RNA stability, Nat. Chem., 2023, 15, 1296-1305.
3. Fang L, Chakraborty S, Dieter EM, Potter ZE, Lombard CK, Maly DJ, Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes, J. Am. Chem. Soc., 2019, 141, 30, 11912-11922.
4. Fang L, Kool ET, Reactivity-Based RNA Profiling for Analyzing Transcriptome Interactions of Small Molecules in Human Cells, STAR Protocols, 2023, 4, 102670.
5. Fang L, Vilas-Boas J, Chakraborty S, Potter ZE, Register AC, Seeliger MA, Maly DJ, How ATP-Competitive Inhibitors Allosterically Modulate Tyrosine Kinases That Contain a Src-like Regulatory Architecture, ACS Chem. Biol., 2020, 15, 7, 2005-2016.
Full list of publications：https://pubmed.ncbi.nlm.nih.gov/?term=linglan%20fang
Contact Us
Email: fanglinglan@westlake.edu.cn