Biography
Hang Shi was born and raised in Shenyang of China. Hang obtained the bachelor's degree with honors in chemical engineering and technology at Hunan University in July 2008. Then he moved to Peking University and pursued his Ph.D. under the tutelage of Prof. Zhen Yang, focusing on natural product synthesis. In September 2013, Hang joined Prof. Tobias Ritter’s lab at Harvard University as a postdoc to develop novel method for fluorination, as well as 18F-labeling in collaboration with Prof. Neil Vasdev and Prof. Steven H. Liang. In November 2015, Hang moved to the Scripps Research Institute and joined Prof. Jin-Quan Yu’s lab as a research associate, and mainly focused on developing regioselective and stereoselective remote C–H bond activation. Hang joined Westlake University to commence his independent studies in 2018, and was awarded Zhongzhou Endowed Assistant Professor. In 2023, Hang was promoted to Associate Professor.
Research
The Shi Research Group is dedicated to the exploration and innovation of novel methodologies in metal-catalyzed reactions and asymmetric catalysis. Recent research endeavors are centered on pioneering catalytic processes for the functionalization and transformation of aromatic molecules through π-coordination, employing meticulously engineered transition metal catalysts. In addition to the catalysis development, the group places a strong emphasis on unraveling the underlying reaction mechanisms. This fundamental understanding forms the bedrock for the future applications of our chemistry.
Representative Publications
1. Xu, L.; Shi, H.* Ruthenium-Catalyzed Activation of Nonpolar C–C Bonds via π-Coordination-Enabled Aromatization. Angew. Chem. Int. Ed. 2023, 62, e202307285.
2. Wu, W.-Q.; Lin, Y.; Li, Y.; Shi, H.* Catalytic Dehydrogenative (3 + 2) Cycloaddition of Alkylbenzenes via π-Coordination. J. Am. Chem. Soc. 2023, 145, 9464.
3. Su, J.; Chen, K.; Kang, Q.-K.; Shi, H.* Catalytic SNAr Hexafluoroisopropoxylation of Aryl Chlorides and Bromides. Angew. Chem. Int. Ed. 2023, 62, e202302908.
4. Li, K.; Wu, W.-Q.; Shi, H.* Asymmetric Hydrogenation of 1,1-Diarylethylenes and Benzophenones through a Relay Strategy. Nat. Commun. 2023, 2170.
5. Li, Y.; Shi, H.* Rhodium-Catalyzed Addition Reactions of Benzylic C–H Bonds to Cyclic N‑Sulfonyl Ketimines via π-Coordination. Chin. Chem. Lett. 2023, DOI: 10.1016/j.cclet.2023.108650.
6. Li, Y.; Wu, W.-Q.; Zhu, H.; Kang, Q.-K.; Xu, L.; Shi, H.* Rhodium-Catalyzed Benzylic Addition Reactions of Alkylarenes to Michael Acceptors. Angew. Chem. Int. Ed. 2022, 61, e202207917.
7. Kang, Q.-K.; Li, Y.; Chen, K.; Zhu, H.; Wu, W.-Q.; Lin, Y.; Shi, H.* Rhodium-Catalyzed Stereoselective Deuteration of Benzylic C–H Bonds via Reversible η6-Coordination. Angew. Chem. Int. Ed. 2022, 61, e202117381.
8. Chen, K.; Kang, Q.-K.; Li, Y.; Wu, W.-Q.; Zhu, H.; Shi, H.* “Catalytic Amination of Phenols with Amines” J. Am. Chem. Soc. 2022, 144, 1144.
9. Xu, L.; Shi, H.* Cobalt-Catalyzed Divergent Functionalization of N-Sulfonyl Amines via β-Carbon Elimination. Sci. China: Chem. 2022, 65, 2214. (Invited)
10. Yan, X.-B.; Li, L.; Wu, W.-Q.; Xu, L.; Li, K.; Liu, Y.-C.; Shi, H.* “Ni-Catalyzed Hydroalkylation of Olefins with N-Sulfonyl Amines” Nat. Commun. 2021, 5881.
11. Kang, Q.-K.; Lin, Y.; Li, Y.; Xu, L.; Li, K.; Shi, H.* “Catalytic SNAr Hydroxylation and Alkoxylation of Aryl Fluorides” Angew. Chem. Int. Ed. 2021, 60, 20391.
12. Li, L.; Liu, Y.-C.; Shi, H.* Nickel-Catalyzed Enantioselective α‑Alkenylation of N‑Sulfonyl Amines: Modular Access to Chiral α‑Branched Amines. J. Am. Chem. Soc. 2021, 143, 4154.
13. Kang, Q.-K.; Lin, Y.; Li, Y.; Shi, H. Ru(II)-Catalyzed Amination of Aryl Fluorides via η6-Coordination. J. Am. Chem. Soc. 2020, 142, 3706.
Prior to Westlake
14. Shi, H.; Lu, Y.; Weng, J.; Bay, K. L.; Chen, X.; Tanaka, K.; Verma, P.; Houk, K. N.*; Yu, J.-Q.* Differentiation and Functionalization of Adjacent, Remote C–H bonds” Nature Chemistry 2020, 12, 399.
15. Shi, H.; Herron, A. N.; Shao, Y.; Shao, Q.; Yu, J.-Q.* Enantioselective Remote meta-C‒H Arylation and Alkylation via a Chiral Transient Mediator. Nature 2018, 558, 581.
16. Shi, H.; Wang, P.; Suzuki, S.; Farmer, M. E.; Yu, J.-Q.* Ligand Promoted meta-C−H Chlorination of Anilines and Phenols. J. Am. Chem. Soc. 2016, 138, 14876.
17. Shi, H.; Braun, A.; Wang, L.; Liang, S. H.*; Vasdev, N.*; Ritter, T.* Synthesis of 18F-Difluoromethylarenes from Aryl (Pseudo) Halides. Angew. Chem. Int. Ed. 2016, 55,10786.
18. Shi, H.; Babinski, D.; Ritter, T.* Modular C−H Functionalization Cascade of Aryl Iodides. J. Am. Chem. Soc. 2015, 137, 3775.
19. Shi, H.; Fang, L.; Tan, C.; Shi, L.; Zhang, W.; Li, C.-C.*; Luo, T.*; Yang, Z.* Total Syntheses of Drimane-Type Sesquiterpenoids Enabled by a Gold-Catalyzed Tandem Reaction. J. Am. Chem. Soc. 2011, 133, 14944.
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