Biography
Li Li received her PhD from the School of Life Sciences at Peking University in 2018, where she studied the development process of human embryonic germ cells and their epigenetic regulations. From 2019 to 2023, she conducted postdoctoral training at Harvard Medical School/Boston Children's Hospital. During this period, she developed single-cell multi-omics lineage tracing mouse model and applied it to study the development and migration process of hematopoietic stem cells. In early 2024, she joined the School of Life Sciences of Westlake University as an assistant professor.
Research
Cell fate choice is a basic biological question, which is involved in organ regeneration, anti-aging, and cancer treatment process. Dr. Li Li developed DARLIN mouse model and Camellia-seq technology to systematically study the lineage relationships, transcriptome, and epigenome of cells in various tissues under physiological or pathological conditions. The molecular characteristics unveiled by these methods provided us with a new understanding of cell proliferation, differentiation, migration, and apoptosis. One the one hand, the laboratory will use the established methods to study the cell fate regulatory mechanism during development, inflammation, and immune response. On the other hand, we are developing new generation of lineage tracing animal models and high-throughput single-cell epigenome lineage tracing technology, which will lay the foundation for a comprehensive understanding of cell fate choice.
Representative Publications
1. Li, L., Bowling, S., McGeary, S. E., Yu, Q., Lemke, B., Alcedo, K., ... & Camargo, F. D. (2023). A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells. Cell, 186(23), 5183-5199.
Research highlighted in Nature Methods (Tang, L. Greater diversity for lineage tracing. Nat Methods 20, 1872 (2023).)
2. Li L., Li, L., Li, Q., Liu, X., Ma, X., Yong, J., ... & Tang, F. (2021), Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution, Cell Research, 31(4), 463-477.
3. Li L., Dong, J., Yan, L., Yong, J., Liu, X., Hu, Y., ... & Qiao, J. (2017), Single-cell RNA-seq analysis maps development of human germline cells and gonadal niche interactions, Cell stem cell, 20(6), 858-873.
4. Wang, R., Liu, X., Li L., Yang, M., Yong, J., Zhai, F., ... & Tang, F (2022), Dissecting human gonadal cell lineage specification and sex determination using a single-cell RNA-seq approach, Genomics, Proteomics & Bioinformatics, 20(2), 223-245.
5. Patel, S.H., Christodoulou, C., Weinreb, C., ...& Li L., Osorio, F.G., Daley, G.Q. and Camargo, F.D. (2022), Lifelong multilineage contribution by embryonic-born blood progenitors, Nature, 606(7915), 747-753.
6. Ji, Q., Zheng, Y., Zhang, G., Hu, Y., Fan, X., Hou, Y., Wen, L., Li, L., Xu, Y., Wang, Y. and Tang, F. (2018), Single-cell RNA-seq analysis reveals the progression of human osteoarthritis, Annals of the rheumatic diseases, annrheumdis-2017.
Contact Us
Email: lili@westlake.edu.cn
Our laboratory is recruiting highly motivated postdocs, PhD students and scientific research assistants. If you are interested, please send your resume and relevant supporting materials as a pdf file to the above email address, and use "Application Position - My Name" as the email title.