Xianjue Ma was born in 1987, and received his Bachelor’s and Ph.D. degrees from Tongji University in 2009 and 2014, respectively. He then worked as a postdoctoral fellow at School of Medicine of Johns Hopkins University (HHMI) (2014 - 2015) and Yale University (HHMI) (2015 - 2019).Dr. Ma has been recruited as an Assistant Professor in School of Life Sciences of Westlake University since June 2019.

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Dr. Xianjue Ma has been working on genetics for more than a decade. By combining genetics with single cell technique, developmental biology, cell biology, and biochemistry, we are dedicated to dissecting the molecular mechanisms of signaling transduction and cell communication during tumorigenesis, using Drosophila (fruit fly), cell line and mouse models. Previously we have performed large scale genetic screens and successfully identified numerous novel components of JNK and Hippo signaling, and revealed their molecular mechanisms in regulating cell death, growth and tumorigenesis. We also identified and named several novel tumor suppressors including Fiery Mountain and Emei. Currently, our lab mainly focuses on the following directions (not limited to):

1. Dissecting the molecular mechanisms of intercellular communication during tumorigenesis.

2. Study the mechanisms of tumor-induced inter-organ communications.  

3. Screen and characterization of novel tumor suppressors or oncogenes.

4. Study the mechanism of tumor suppressive cell competition.

5. Mechanistic study of organ size control.

(# equal contribution, * corresponding author)

1. 1. Yang, S., Jiang, H., Guo, Y., Song, S., Xu, W., Zheng, J., Bian, W., Wu, C., Ding, X., Guo, X., Xue, L., Ryoo, H., Li, X.*, Ma, X.* (2022) Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1/Xbp1s activation. PNAS, 119(42):e2202133119.

2. Kong, D., Sihua Zhao, S., Xu, W., Dong, J., Ma, X.* (2022) Fat body-derived Spz5 remotely facilitates tumor-suppressive cell competition through Toll-6-α-Spectrin axis-mediated Hippo activation. Cell Rep, 39(12):110980.

3. Liu, P., Guo, Y., Xu, W., Lu, J., Li, X., Wang, X., Richardson, H., Ma, X.* Ptp61F integrates Hippo, TOR and actomyosin pathways to control three-dimensional organ size. 2022, Cell Rep, 41 (7):111640.

4. Bian, W.#, Tang, M.#, Jiang, H.#, Xu, X.#, Hao, W.#, Sui, Y.#, Hou, Y., Nie, L., Zhang, H., Wang, C., Li, N., Wang, J., Qin, J., Wu, L.*, Ma, X.*, Chen, J*, Wang, W.*, Li, X.* (2021) Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation., Dev Cell, 56(20):2902-2919.e8.

5. Guo, X.#, Sun, Y.#, Azad, T., Rensburg, L., Luo, J., Yang, S., Liu, P., Lv, Z., Zhan, M., Lu, L., Zhou, Y., Ma, X.*, Zhang, X.*, Yang, X.*, Xue, L.* (2020) Rox8 promotes microRNA-dependent yki messenger RNA decay. PNAS, 117(48):30520- 30530.

6.  Ma X*#, Lu JY, Moraru A, Teleman AA, Fang J, Qiu Y, Liu P, Xu T#. A Novel Regulator of ER Ca²⁺ drives Hippo-mediated Tumorigenesis. Oncogene. 2019, doi: 10.1038/s41388-019-1076-z.

7. Ma X#*, Guo X#, Richardson H, Xu T, Xue L*. POSH Regulates Hippo Signaling Through Ubiquitin-Mediated Expanded Degradation. PNAS. 2018, 115(9): 2150-2155.

8. Ma X*, Wang H, Jie J, Xu W, Sun Y, Li W, Zhang X*, Chen J*, Xue L*. Hippo Signaling Promotes JNK-dependent Cell Migration. PNAS. 2017, 114(8):1934-1939.

Link for a complete publication list: 

https://scholar.google.com/citations?user=R1FWynkAAAAJ&hl=zh-CN 

Our lab currently has multiple opening positions for postdoctoral fellow and research assistant. If you are interested, please send your CV to email：maxianjue@westlake.edu.cn