Dr. Huaizong Shen received his Bachelor of Science degree from the School of Life  Sciences, Shandong University in 2012, and his Ph.D. degree in Biology from  Tsinghua University in 2017. After that, he continued his research in Tsinghua  University as a postdoc during which period he was awarded the Outstanding  Scholar Award from the Beijing Advanced Innovation Center for Structural  Biology. Up till now, Dr. Shen has published a series of seminal research papers  in Science and  other high-profile  journals.

Neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and Huntington’s disease, affect patients by causing serious damages to specific regions of human brains which are responsible for important functions, such as memory, learning comprehension, and judgement. In contrast to the tremendous burdens caused by neurodegenerative diseases to human society, our knowledge of the molecular mechanisms underlying these diseases remain very much lacking. Our lab aims to solve the puzzles of these diseases with combined methods of biochemistry, structural biology and cell biology. Our work mainly focuses on illuminating the working mechanisms of key protein players, identifying unknown crucial components and connecting these experimental evidences together so to get closer toward the final truth.

1. Tian Li*, Kun Wu*, Zhenlei Yue*, Yifei Wang, Fan Zhang, Huaizong Shen^# (2020). Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs. Molecular Cell. (*co-first authors, ^#correspondence author,下同)

2. Huaizong  Shen*, Dongliang  Liu*, Kun  Wu, Jianlin Lei, Nieng Yan (2019). Structures of human Na_v1.7  channel in complex with auxiliary subunits and animal toxins. Science, eaaw2493. (* equal  contribution)

3. Xiaojing  Pan*,  Zhangqiang Li*,  Qiang Zhou*, Huaizong  Shen*,  Kun Wu*,  Xiaoshuang Huang, Jiaofeng Chen, Juanrong Zhang, Xuechen Zhu, Jianlin Lei, Wei  Xiong, Haipeng Gong, Bailong Xiao, Nieng Yan (2018). Structure of the human  voltage-gated sodium channel Na_v1.  4 in complex with β1. Science,  eaau2486. (* equal  contribution)

4. Huaizong Shen*, Zhangqiang Li*, Yan Jiang*, Xiaojing Pan*, Jianping Wu,  Ben Cristofori-Armstrong, Jennifer J. Smith, Yanni K. Y. Chin, Jianlin Lei,  Qiang Zhou, Glenn F. King, Nieng Yan (2018). Structural basis for the modulation  of voltage-gated sodium channels by animal toxins. Science,  eaau2596. (* equal  contribution)

5. Huaizong  Shen*, Qiang Zhou*,  Xiaojing Pan*, Zhangqiang Li*, Jianping Wu*, Nieng Yan (2017). Structure of a  eukaryotic voltage-gated sodium channel at near-atomic  resolution. Science, 355(6328),  eaal4326. (* equal  contribution)

6. Wei  Peng*, Huaizong  Shen*, Jianping  Wu*, Wenting Guo, Xiaojing Pan, Ruiwu Wang, S.R.Wayne Chen, Nieng Yan (2016).  Structural basis for the gating mechanism of the type 2 ryanodine receptor  RyR2. Science, 354(6310),  aah5324. (* equal  contribution)

7. Xiaojing  Pan*,  Zhangqiang Li*,  Xiaoshuang Huang*, Gaoxingyu  Huang*, Shuai  Gao, Huaizong  Shen, Lei  Liu, Jianlin Lei, Nieng Yan (2019). Molecular basis for pore blockade  of human Na⁺ channel  Na_v1.2 by  the μ-conotoxin KIIIA. Science,  eaaw2999. (* equal  contribution)

8. Zhen Yan*,  Qiang Zhou*, Lin Wang*, Jianping Wu*, Yanyu Zhao, Gaoxingyu Huang, Wei  Peng, Huaizong  Shen, Jianlin Lei,  Nieng Yan (2017). Structure of the Na_v1.4-β1 Complex  from Electric Eel. Cell.  170(3), 470-482.  e11. (* equal  contribution)

Positions Opening

Postdoctoral Associate/Fellow

Multiple postdoc positions are available in the lab. We are seeking sharp, experienced, creative and independent scientists who have excellent molecular or structural biology skills. Strong publication record in peer-reviewed journals and outstanding clarity of thought in communications are preferred. Internationally competitive salary and benefits (including social insurance, medical insurance, etc.) are provided. 

Research Assistant

Multiple research assistant positions are available in the lab. Expertise in molecular or structural biology is preferred. Internationally competitive salary and benefits  (including social insurance, medical insurance, etc.) are provided.