Dr. Ruixue Wan received her bachelor's degree from Sun Yat-sen University in 2013 and her Ph.D. from Tsinghua University in 2018. She did her postdoctoral research in School of Medicine, Tsinghua University.

Biomacromolecules in cells often form protein machineries or complexes to function. Take the spliceosome as an example, to execute pre-mRNA splicing, hundreds of spliceosomal components need to recognize the substrates, undergo stepwise assembly and activation, catalyze the reactions, and release the products. Dr. Ruixue Wan has made important contributions to the elucidation of the molecular mechanism of RNA splicing by uncovering atomic structures of the spliceosome, greatly advancing our understanding of this fundamental biological process for all eukaryotes. At present, our research will mainly conduct research on the working mechanism of important cellular macromolecular machines from structural biology, biochemistry, biophysics and other aspects, focusing on (but not limited to) the molecular mechanism of U12-type splicing, the structural basis of alternative splicing and RNA processing, as well as the structure and mechanism of other important molecular complexes.

(* authors have equal contribution, ^†corresponding author)

1.  Rui Bai*, Ruixue Wan*^†, Lin Wang, Kui Xu, Qiangfeng Zhang, Jianlin Lei, & Yigong Shi^†. Structure of the activated human minor spliceosome. Science, 2021, 371(6535):eabg0879

2. Rui Bai*, Ruixue Wan*^† Chuangye Yan*, Qi Jia, Jianlin Lei, & Yigong Shi^†. Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 2021, 371(6525):eabe8863

3. Ruixue Wan*, Rui Bai*, Chuangye Yan, Jianlin Lei, & Yigong Shi^†. Structures of the catalytically activated yeast spliceosome reveal the mechanism of branching. Cell, 2019, 177, 339-351

4. Ruixue Wan^†. A key component of gene expression, revealed. Science, 2018, 362(6417):904.

5. Rui Bai*, Ruixue Wan*, Chuangye Yan*, Jianlin Lei, & Yigong Shi^†. Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation. Science, 2018, 360(6396):1423-1429

6. Rui Bai*, Chuangye Yan*, Ruixue Wan*, Jianlin Lei, & Yigong Shi^†. Structure of the post-catalytic spliceosome from Saccharomyces cerevisiae. Cell, 2017, 171, 1589-1598

7. Ruixue Wan*, Chuangye Yan*, Rui Bai*, Jianlin Lei, & Yigong Shi^†. Structure of an intron lariat spliceosome from Saccharomyces cerevisiae. Cell, 2017, 171, 120-132.

8. Chuangye Yan*, Ruixue Wan*, Rui Bai*, Gaoxingyu Huang, & Yigong Shi^†. Structure of a yeast step II catalytically activated spliceosome. Science, 2017, 355(6321):149-155.

9. Ruixue Wan*, Chuangye Yan*, Rui Bai*, Gaoxingyu Huang*, & Yigong Shi^†. Structure of a yeast catalytic step I spliceosome at 3.4-angstrom resolution. Science, 2016, 353(6302):895-904.

10. Chuangye Yan*, Ruixue Wan*, Rui Bai*, Gaoxingyu Huang, & Yigong Shi^†. Structure of a yeast activated spliceosome at 3.5-angstrom resolution. Science, 2016, 353(6302):904-911.

11. Ruixue Wan*, Chuangye Yan*, Rui Bai, Lin Wang, Min Huang, Catherine C. L. Wong, & Yigong Shi^†. The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis. Science, 2016, 351(6272):466-475.

12. Jing Hang*, Ruixue Wan*, Chuangye Yan*, & Yigong Shi^†. Structural basis of pre-mRNA splicing. Science, 2015, 349(6253):1191-1198.

13. Chuangye Yan*, Jing Hang*, Ruixue Wan*, Min Huang, Catherine C. L. Wong, & Yigong Shi^†. Structure of a yeast spliceosome at 3.6-angstrom resolution. Science, 2015, 349(6253):1182-1191.

Complete publication list:

https://scholar.google.com/citations?hl=zh-CN&pli=1&user=qHit384AAAAJ

Email: wanruixue@westlake.edu.cn

We have several open positions for graduate students, postdoctoral fellows, staff scientists, and research assistants. We hope to create a free and welcoming research environment, encourage members to develop their talents and interests and pursue significant scientific questions while providing high-quality scientific research training. Awaiting your participation!