Biography
Dr. Wu obtained his bachelor’s degree from Tsinghua University in 2012 and received his PhD degree in Structural biology from Tsinghua University in 2017. He then worked as a postdoc at Princeton University. His research was focused on molecular mechanism of membrane proteins including ion channels and transporters. His work has been published in Cell, Nature, Science, etc. Dr. Wu joined Westlake University as an Assistant Professor in 2019.
History
2021
The First Zhejiang Province Youth Science and Technology Talent Award
2017
Wu Ray Prize
2017
Beijing Outstanding Ph.D. Student Award
2017
Tsinghua University Outstanding Ph.D. Student Award
2017
Tsinghua University Academic Excellence Award
2021
Zhejiang Province Natural Science Outstanding Youth Fund
Research
1. Mechanistic understanding of the fertilization process;
2. Structural investigations on disease-related proteins and protein complexes;
3. Structure-based drug development.
Representative Publications
1. Lin, S.*, Ke, M.*, Zhang, Y., Yan, Z., Wu, J. (2021). Structure of a mammalian sperm cation channel complex. Nature 595, 746-750.
Highlighted by News and Views in Nature:
Clapham, D., Hulse, R. (2021) Sperm CatSper ion channel swims into sharper focus. Nature 595, 654-655
2. Xie, J.*, Ke, M.*, Xu, L.*, Lin, S., Zhang, J., Yang, F. #, Wu, J. #, Yan, Z. # (2020). Structure of the human sodium leak channel NALCN in complex with FAM155A. Nat Commun 11, 5831.
3. Zhao, Y.*, Huang, G.*, Wu, J.*#, Wu, Q., Gao, S., Yan, Z., Lei, J., and Yan, N#. (2019). Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel. Cell 177, 1495-1506 e1412. (*co-first author #co-corresponding author)
4. Wu, J.*, Yan, Z.*, Li, Z.*, Qian, X., Lu, S., Dong, M., Zhou, Q., and Yan, N. (2016). Structure of the voltage-gated calcium channel Cav1.1 at 3.6 A resolution. Nature 537, 191-196. (Ranked in the top ten Science and Technology Progress of China's universities in 2016)
5. Wu, J., Yan, N., and Yan, Z. (2017). Structure-Function Relationship of the Voltage-Gated Calcium Channel Cav1.1 Complex. Advances in experimental medicine and biology 981, 23-39.
6. Wu, J.*, Yan, Z.*, Li, Z., Yan, C., Lu, S., Dong, M., and Yan, N. (2015). Structure of the voltage-gated calcium channel Cav1.1 complex. Science 350, aad2395.
7. Peng, W.*, Shen, H.*, Wu, J.*, Guo, W., Pan, X., Wang, R., Chen, S.R., and Yan, N. (2016). Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2. Science 354, aah5324.
8. Yan, Z.*, Zhou, Q.*, Wang, L.*, Wu, J.*, Zhao, Y., Huang, G., Peng, W., Shen, H., Lei, J., and Yan, N. (2017). Structure of the Nav1.4-beta1 Complex from Electric Eel. Cell 170, 470-482 e411.
9. Shen, H.*, Zhou, Q.*, Pan, X.*, Li, Z.*, Wu, J.*, and Yan, N. (2017). Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science 355, aal4326.
10. Bai, X.C.*, Yan, Z.*, Wu, J.*, Li, Z., and Yan, N. (2016). The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening. Cell research 26, 995-1006.
11. Gong, X.*, Qian, H.*, Zhou, X.*, Wu, J.*, Wan, T.*, Cao, P., Huang, W., Zhao, X., Wang, X., Wang, P., et al. (2016). Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. Cell 165, 1467-1478.
12. Huang, X.*, Luan, B.*, Wu, J.*, and Shi, Y. (2016). An atomic structure of the human 26S proteasome. Nat Struct Mol Biol 23, 778-785.
13. Deng, D.*, Xu, C.*, Sun, P.*, Wu, J.*, Yan, C., Hu, M., and Yan, N. (2014). Crystal structure of the human glucose transporter GLUT1. Nature 510, 121-125. (Ranked in the top ten China Technology Progress in 2014)
14. Yan, Z., Bai, X.C., Yan, C., Wu, J., Li, Z., Xie, T., Peng, W., Yin, C.C., Li, X., Scheres, S.H., et al. (2015). Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature 517, 50-55.
Full publication list：https://www.ncbi.nlm.nih.gov/myncbi/1TK2UfmBv5y5m/bibliography/public/
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