Biography
Dr. Dong is a Chair Professor at Westlake University, where he also is Vice President and Dean of School of Medicine. Dr. Dong served as a Chair Professor of Immunology and the Director of the Center for inflammation and Cancer at the University of Texas MD Anderson Cancer Center before his move to China. He was Dean of Tsinghua University School of Medicine in 2016-2020 and Director of Institute of Immunology at Tsinghua University in 2014-2021, and Associate Vice President at Shanghai Jiao Tong University Schools in 2022-2023, and Director for the Shanghai Immune Therapy Institute from 2021.
Research
Dr. Dong’s research is to understand the molecular mechanisms whereby immune and inflammatory responses are normally regulated, and to apply this knowledge to the understanding and treatment of infection, autoimmunity and allergy disorders as well as cancer. The work from Dr. Dong’s group has led to the discoveries of Th17 and T follicular helper (Tfh) cell subsets in the immune system and elucidation of their biological and pathological functions.
Dr. Dong has over 200 publications and was rated highly cited researcher for seven times. The honors he has received include the 2009 American Association of Immunologists-BD Bioscience Investigator Award, 2019 International Cytokine and Interferon Society Biolegend-William E. Paul Award, and 2024 Distinguished Fellow of American Association of Immunologists. He is a member of the Chinese Academy of Sciences and a fellow of the American Association for the advancement of Science and the Chinese Academy of Medicine. He is currently co-editor-in-chief for Current Opinion in Immunology and hLife, Editor-in-chief for Frontiers in Immunology- T Cell Biology, Executive Associate Editor for China Sciences- Life Sciences, Associate Editor for Advances in Immunology, and an Editor for Annual Review of Immunology Immunity, and Journal of Experimental Medicine, and a Scientific Advisor for Med.
Representative Publications
1. Heon Park; Zhaoxia Li; Xuexian O Yang; Seon Hee Chang; Roza Nurieva; Yi-Hong Wang; Ying Wang; Leroy Hood; Zhou Zhu; Qiang Tian; Chen Dong ; A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17, Nature Immunology, 2005, 6(11): 1133-1141
2. Nurieva, Roza I; Chung, Yeonseok; Martinez, Gustavo J; Yang, Xuexian O; Tanaka, Shinya; Matskevitch, Tatyana D; Wang, Yi-Hong; Dong, Chen ; Bcl6 mediates the development of T follicular helper cells., Science, 2009, 325(5943): 1001-1005
3. Liu Xindong; Wang Yun; Lu Huiping; Li Jing; Yan Xiaowei; Xiao Minglu; Hao Jing; Alekseev Andrei; Khong Hiep; Chen Tenghui; Huang Rui; Wu Jin; Zhao Qiwen; Wu Qi; Xu Senlin; Wang Xiaohu; Jin Wei; Yu Shicang; Wang Yan; Wei Lai; Wang Aibo; Zhong Bo; Ni Ling; Liu Xiaolong; Nurieva Roza; Ye Lilin; Tian Qiang; Bian Xiu Wu; Dong Chen ; Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction, Nature, 2019, 567(7749): 525-+
4. Huang, J.; Lee, H. Y.; Zhao, X.; Han, J.; Su, Y.; Su, Y.; Shao, J.; Ge, J.; Zhao, Y.; Bai, X.; He, Y.; Wang, X.; Wang, X.; Dong, C. ; Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93, Immunity, 2021, 54(4): 673-686
5. Qinli Sun; Dongli Cai; Dingfeng Liu; Xiaohong Zhao; Ruifeng Li; Wei Xu; Bowen Xie; Mengting Gou; Kun Wei; Yuling Li; Jinling Huang; Xinxin Chi; Peng Wei; Jing Hao; Xinyi Guo; Birui Pan; Yujie Fu; Ling Ni; Chen Dong ; BCL6 promotes a stem-like CD8+ T cell program in cancer via antagonizing BLIMP1, Science Immunology, 2023, 8(88)
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